Vaccination

CDC recommends a yearly flu vaccine as the first and most important step in protecting against flu viruses.
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Stop Germs

Cover your nose and mouth with a tissue when you cough or sneeze. Throw the tissue in the trash after you use it.
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Antiviral Drugs

Antiviral drugs can make illness milder and shorten the time you are sick. They may also prevent serious flu complications.
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The flu is a pretty bad deal. It's very contagious and can lead to hospitalization and even death. While these steps won't guarantee you will not get the disease, they give you the best chances of prevention.